Live-attenuated vaccines and immunoglobulins or blood products
Alternative title: Immunoglobulin, Blood products
Live-attenuated vaccines such as measles-mumps-rubella (MMR), measles-mumps-rubella-varicella (MMRV), varicella (chickenpox) or zoster (shingles) vaccination may be affected by circulating antibodies in immunoglobulin therapy or blood products. This includes normal human immunoglobulin therapy for conditions like Kawasaki’s disease or a blood transfusion for treatment of a medical condition.
There have been guidelines developed that outline the recommended intervals between either immunoglobulins or blood products and these live attenuated vaccines.(see resource link below)
Note that inactivated (non-live) vaccines can be safely administered following immunoglobulins or blood products.
The Immunisation Handbook 10th edition table 3.3.6 has recommended intervals between either immunoglobulins or blood products and MMR, MMRV, varicella or zoster vaccination.
Reviewed by: Georgina Lewis – Clinical manager and Nigel Crawford (Paediatrician, The Royal Children’s Hospital, Melbourne)
Date: November 2016
Materials in this section are updated as new information and vaccines become available. The Melbourne Vaccine Education Centre (MVEC) staff regularly reviews materials for accuracy.
You should not consider the information in this site to be specific, professional medical advice for your personal health or for your family’s personal health. For medical concerns, including decisions about vaccinations, medications and other treatments, you should always consult a healthcare professional.
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The Melbourne Vaccine Education Centre (MVEC) is a new web-based initiative, providing up-to-date immunisation information for healthcare professionals, parents and the public.
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